We all know that eight hours of sleep is essential for optimal health. But when you have 100 things on your mind, even the binge-watching session and relaxing herbal teas can’t help you get that quality shut-eye. That’s where cannabidiol for sleep comes in.

Unlike traditional sleeping pills, these products can help you get a restful night’s sleep without the harsh side effects. Plus, they’re available in different forms, including gummies, oils, and capsules.

The best part? You don’t need a prescription or doctor’s note to buy it. In this article, we’ll review the best sleep cannabidiol products that’ll make endless tossing and turning a thing of the past, starting with our all-time favorite FOCL Deep Sleep Gummies.

Where To Buy CBD for Sleep

Best CBD for Sleep: First Look

When choosing a cannabidiol for sleep, it’s important to look for one with a strong dose of CBD, complemented by other supportive cannabinoids like CBN.

We also focused on selecting products that have clean, high-quality ingredients and are priced affordably. Our top choice is FOCL’s Deep Sleep Gummies, closely followed by CBDistillery’s offering.

FOCL Deep Sleep Gummies — Best CBD Gummies for Sleep

Pros:

  • May improve focus and relieve pain

  • Micro-dose THC for optimal relaxation

  • Vegan-friendly formula

  • Non-GMO and gluten-free

  • Easy to administer

Con:

  • May take time to deliver noticeable results

If you spend all night tossing and turning, FOCL Deep Sleep Gummies might help resolve your sleep woes. These CBD gummies for sleep contain soothing ingredients that may help mellow out your frantic mind while your body gets the rest it needs.

Plus, it’s vegan-friendly, so you can confidently include it in your night routine. These CBD gummies for sleep contain L-theanine, which can alter brain chemistry, so it may not be the best choice for people taking antidepressants, sedatives, and anti-seizure drugs.

FOCL Deep Sleep Gummies contain 100mg L-theanine, 25mg CBD, 15mg CBN, 2.5 mg of THC, and only 1 mg of melatonin.

These CBD gummies for sleep can calm your nervous system and relax your body. A 28-day independent study with 179 participants found that people got an average of 1 hour and 48 minutes of extra sleep each night.

Three out of four participants fell asleep faster, while 87% called Deep Sleep the best sleep aid they’ve ever used. Unlike other prescription sleep medicine, these gummies are not habit-forming, so you won’t feel like using them just to get quality shuteye.

These CBD gummies for sleep come in a tangy sour blue raspberry flavor that’s genuinely fun to chew.

One jar containing 30 gummies will cost $69. That’s about $2.30 per gummy to ease you into slumber. If you subscribe, you’ll also get 20% off along with other perks such as free shipping, reward points, volume discounts, and 60 day guarantee.

FOCL Deep Sleep Gummies hit that sweet spot of relaxation without knocking you out cold. Besides sleep support, FOCL’s range also includes products for focus, mood, and even intimacy. Each product is free from harmful allergens and lab-tested for purity.

>>Check the best prices for FOCL Deep Sleep Gummies

CBDistillery shhh 300mg CBN + 900mg CBD Oil Tincture — Best CBD oil for Sleep

Pros:

  • High-potency formula to relieve tension

  • Supports natural sleep cycle

  • Help you stay asleep for longer

  • Formulated with 100% clean ingredients

  • 60 day money back guarantee

Con:

  • Taste may not appeal to all

Struggling with a poor sleep cycle? This cbd for sleep packs a punch with 300mg CBN and 900mg CBD to help reset your circadian rhythm. Just drop some under your tongue before bed and you can expect a more consistent sleep pattern.

Although CBDistillery shhh isn’t quite potent, CBN may cause excessive drowsiness, dry mouth, and changes in appetite.

The CBDistillery tincture brings you a solid 1:3 ratio of CBN to CBD — that’s 300mg CBN paired with 900mg CBD. Since the THC is less than 0.3%, you won’t feel spaced out.

This sleep tincture interacts with your endocannabinoid system to help calm your overactive brain and keep your sleep cycle in check. This means you’re less likely to have those crazy, 3 a.m. wide-awake moments. It also helps to reduce anxiety and stress, which can be a major factor in insomnia.

CBDistillery’s sleep tincture offers a mild hemp taste with a subtle hint of earthiness. CBDistillery shhh cannabidiol for sleep is available for $100. If you subscribe to their plan, the brand will provide 30% off, bringing the cost down to $70.

CBDistillery’s cannabidiol for sleep is a powerhouse for sleep support. The blend is lab-tested and free from harmful chemicals, ensuring you get a safe and effective product.

>>Check the best prices for CBDistillery shhh 300 mg CBN + 900 mg CBD Oil Tincture

Exhale Wellness CBD + CBN SLEEP GUMMIES — Best CBN + CBD Gummies for sleep

Pros:

  • Provides peaceful sleep without interruptions

  • Discreet, bite-sized and portable

  • Delectable natural fruit flavors

  • Free from harmful color and preservatives

  • 20% off on the first order

Con:

  • A bit more expensive than the alternatives

If conventional sleep aids make you feel groggy the next day, Exhale Wellness CBD + CBN Sleep Gummies are worth a try. They combine hemp-derived CBD and CBN distillate with melatonin to create a balanced, natural sleep experience, whether you need a power nap or a full night’s rest.

If you’re looking for a quick fix, these gummies might not be the best choice. These CBD gummies for sleep can work wonders over time, so you must be patient to see results. Each gummy packs a punch with 25mg of CBD, 10mg of CBN, and a generous 5mg of melatonin.

Exhale Wellness CBD gummies for slep are formulated for those nights when counting sheep just isn’t cutting it, or you’re tired of watching the 10th episode of your favorite series. They help calm your mind and recover your body after a tiring day. Besides improving sleep quality, they can also be taken when you just want a quick power nap.

Exhale Wellness CBN + CBD Sleep Gummies offer assorted natural fruit flavors, from tropical notes to berry bursts. If gummies are your go-to, Exhale Wellness has a pack of 30 for $59.99. At Exhale Wellness, the more you buy, the more you’ll save. You can get two packs for $110.91 or go all-in with three for $152.87.

Exhale Wellness gummies are a good pick for anyone who loves a nighttime snack that boosts sleep. They’re tasty and functional. Plus, free shipping on orders over $80 and a 30-day money-back guarantee sweeten the deal.

>>Check the best prices for Exhale Wellness CBD + CBN Sleep Gummies

Tommy Chong’s Nice Dreams Sleep Tincture 2-Pack — Best CBD Tincture for Sleep

Pros:

  • Help with restorative sleep

  • Free from harsh chemicals

  • No gluten, soy, and other preservatives

  • Fast-absorbing formula

  • Accepts various payment methods

Con:

  • Dosage might be too high for some

Looking for an all-rounded experience that not only solves your sleep issues but also gives you that “peace of mind” feeling? Tommy Chong’s Nice Dreams Sleep Tincture 2-Pack is here to save the day—or night, in this case.

This tincture doesn’t just put you to sleep; it helps calm your nerves and support a healthy mood so you can complete your tasks without feeling anxious.

This cannabidiol for sleep requires 20 drops sublingual, which might not be ideal for those who can’t measure doses or manage a dropper. Plus, the flavor can be a bit off-putting for sensitive palates.

Crafted from pure American-grown hemp, these tinctures pack nano CBD for quick absorption, along with other sleep enhancing ingredients like GABA, melatonin and Cordyceps Sinensis. The latter offers anti-aging benefits so you will wake up with a fresh face despite sleeping a little late.

This sleep tincture is designed for therapeutic targets to help you hit those deep sleep states. Plus, it boasts GABA to help with cellular repair while you snooze.

Thanks to the beneficial ingredients, it may also boost your longevity, brain health conditions, mood, focus, and even heart health conditions. The effects of this product are felt within 30 minutes and last for up to 8 hours.

Tommy Chong’s Nice Dreams Sleep Tincture has a pleasant taste. The formula is not too thick or runny — but just perfect, making it easy to administer. Two bottles of Tommy Chong’s cannabidiol for sleep are priced at $79.95. This way, you’re doubling up on your sleep aid while keeping your wallet happy.

When Tommy Chong puts his name on a product, you know it’s got to be good. This Nice Dreams Sleep Tincture has the legendary comedian’s stamp of approval, and it’s even been featured in some big-name publications.

The only downside? The 20-drop CBD dosages means you might go through a bottle faster than you’d like, but for the quality of sleep, it’s worth every drop.

>>Check the best prices for Tommy Chong’s Nice Dream Sleep Tincture 2-Pack

CBDPure Sleep — Best for Sleep Disorders

Pros:

  • Helps fall asleep faster and stay asleep longer

  • Quality tested for purity

  • Acts within half an hour

  • Non-habit forming formula

  • 100% risk-free money-back guarantee

Con:

  • Sublingual usage might be difficult for some.

If you still can’t get decent sleep even after consuming herbal teas and other natural remedies, CBDPure Sleep could be what you need. This CBD oil contains sleep-inducing ingredients like organic MCT coconut oil, full-spectrum hemp extracts, and botanical terpenes, so you can sleep like a baby and wake up energetic.

The fast-acting formula helps you to sleep within 30 to 60 minutes. Thanks to its quality-tested ingredients, you can consume it every night without worrying about long-lasting, harmful side effects.

While CBDPure Sleep is quite beneficial for people with sleep disorders, this sleep tincture contains linalool, which might cause depressive effects. It could also lead to digestive irritation when consumed orally, so people suffering from gastritis or other stomach issues should use it carefully.

Formulated in a cGMP-certified facility, each drop gives you 50mg of CBD, 5mg of CBN, and a hint of 2.5mg of THC to ease you into good night’s sleep.

Known for its calming and balanced formula, this product can help promote a restful night’s sleep. It’s perfect for when you need to wake up feeling refreshed and ready to take on the day without that morning confusion.

Infused with MCT oil, this oil has a mild and pleasant flavor, making it easy to incorporate into your nightly routine. Clocking in at $159.99, CBDPure Sleep may be a bit of a splurge. That said, if you’re willing to pay a premium for your bedtime routine, this could be for you.

CBDPure Sleep is for those nights when you just can’t seem to switch off your mind and go to sleep. The potent formula is also ideal for tackling sleep disorders like insomnia, restless leg syndrome, and even general anxiety.

>>Check the best prices for CBDPure Sleep

Medterra Sleep Tight Gummies — Best for Jet Lag

Pros:

  • Helps with restorative slumber and deep relaxation

  • Formulated with soothing ingredients

  • US-Hemp Authority certified

  • Comes with a certificate of analysis

  • Personalized dosage

Con:

  • Only available in one-strength

Medterra Sleep Tight Gummies are best for beginners trying CBD products for the first time, but aren’t quite ready for stronger options yet. With only 25 mg of CBD per gummy, it’s enough to improve sleep quality and promote deep relaxation without overwhelming you.

These gummies are sprinkled with sugar, so if you’re diabetic, you must steer clear to avoid any spikes in your blood sugar levels. The sugar content could also be a dealbreaker for those on a strict diet.

Medterra combines powerful CBD with natural sleep enhancers like chamomile and passionflower. Besides that, it contains calming lemon balm, melatonin, and L-theanine, along with added boosters like 5HTP, which makes it perfect for unwinding before bed.

Medterra gummies are formulated to help you get rejuvenated and restful sleep. They’re especially great for light sleepers who wake up at the slightest noise. Plus, they’re a lifesaver for overcoming jet lag.

Medterra Sleep Tight Gummies feature a blackberry lemon flavor, complemented by a light sugar coating. This combination offers a balanced fruity taste with a slightly tart finish that lingers on your palate for a while.

If you want to keep things simple and affordable, Medterra Sleep Tight Gummies are priced at $45.99. They also come with fast shipping and a 30-day satisfaction guarantee.

Medterra Sleep Tight Gummies are like your nighttime ritual in a tasty little package. These gummies have a balanced mix of CBD, chamomile, and melatonin, which work together to gently nudge you into sleep while you wake up a whole lot chipper.

And let’s be honest; the fruity flavor is a nice bonus when craving a little treat before bed.

>>Check the best prices for Medterra Sleep Tight Gummies

Cornbread Hemp Sleep Gummies – Best Melatonin-Free Formula

Pros:

  • USDA-certified organic ingredients

  • Melatonin-free formula for natural sleep support

  • Vegan and gluten-free

  • Full-spectrum hemp extract with up to 2 mg THC per serving

Con:

  • Slightly stronger natural hemp flavor

If you’re looking for an organic, plant-based way to improve your sleep, Cornbread Hemp CBD Sleep Gummies are worth considering. Made with USDA-certified organic ingredients, these gummies combine full-spectrum hemp extract with naturally calming botanicals like organic valerian root, chamomile and lavender to help you unwind and drift off to sleep.

Unlike many sleep aids, these gummies are melatonin-free, which makes them an excellent option for those who want a natural alternative without the risk of morning grogginess. Each gummy contains up to 2 mg of THC (within legal limits) and either 25 mg or 50 mg of CBD, depending on the strength you choose.

Cornbread Hemp CBD Sleep Gummies are designed to promote relaxation and improve sleep without becoming habit-forming. While their natural hemp flavor may be noticeable, many users appreciate the gummies’ smooth texture and organic composition.

A jar of 30 gummies costs $49.99 for the 750 mg option (25 mg CBD per gummy) or $74.99 for the 1500 mg option (50 mg CBD per gummy). Subscribing not only saves you 20% but also includes free shipping, making these gummies more accessible for long-term use.

Cornbread Hemp Sleep Gummies offer a simple, effective way to relax before bedtime. Just take one gummy 30 minutes before sleep, and let the full-spectrum hemp extract work its magic. Whether you’re managing occasional insomnia or seeking a nightly sleep aid, these gummies provide a high-quality, organic solution for restful nights.

>>Check the best prices for Cornbread Hemp CBD Sleep Gummies

What Is CBD?

CBD, or cannabidiol, is a naturally occurring compound found in the cannabis plant. Unlike THC, which is known for its psychoactive effects, CBD doesn’t get you high.

Instead, it’s celebrated for its potential therapeutic health benefits, which include reducing anxiety, alleviating pain, and promoting relaxation.

If you’re new to CBD found in cannabis plant or have been simply exploring its uses, CBD is a versatile option that can be easily incorporated into your wellness routine through oils, gummies, capsules, and more.

How Does CBD Work for Sleep?

If you’ve been struggling with sleep issues, CBD found in cannabis plants might be just what you need. CBD works by interacting with your body’s endocannabinoid system (ECS), which plays a crucial role in regulating various functions, including sleep.

When you take CBD, it can help balance your ECS, promoting relaxation and reducing the factors that often keep you awake, such as anxiety or discomfort.

Unlike some sleep aids that can leave you feeling groggy, CBD offers a natural way to improve your sleep quality without those unwanted side effects.

CBD and the Endocannabinoid System

To understand how CBD works for sleep, it’s essential to know about the endocannabinoid system. The ECS is a complex network of receptors and neurotransmitters that helps maintain balance in your body.

When CBD interacts with the ECS, it influences receptors involved in regulating sleep, mood, and stress.

By supporting the ECS, CBD can help promote a more restful and restorative sleep, making it easier for you to wake up feeling refreshed and ready to take on the day.

>>Check the best prices for FOCL Deep Sleep Gummies

How Can CBD Benefit Sleep?

CBD has gained popularity as a natural sleep aid, offering potential relief for various sleep-related issues. Let’s explore how CBD might benefit your sleep by addressing some common issues.

Insomnia

If you’re dealing with insomnia, CBD may help by calming your mind and body, making it easier to fall asleep and stay asleep [1].

Clinical data shows that its ability to reduce anxiety and promote relaxation can be particularly beneficial for those who have trouble falling asleep.

Chronic Pain

Chronic pain is a significant barrier to restful sleep. Relevant animal studies and human ones show that CBD’s anti-inflammatory and analgesic properties can help alleviate pain, allowing you to sleep more comfortably through the night [2].

By addressing the root cause of your discomfort, CBD may improve your overall sleep quality.

Anxiety

Anxiety is a common culprit behind sleepless nights. CBD works by interacting with serotonin receptors in your brain, which can help reduce feelings of anxiety.

With less anxiety weighing on your mind, you may find it easier to drift off into a peaceful sleep.

Circadian Rhythm Disorders

For those with circadian rhythm disorders, CBD may help regulate your sleep-wake cycle. By supporting your body’s natural rhythms, CBD can make it easier to fall asleep at the right time and wake up feeling refreshed.

Restless Leg Syndrome

Restless Leg Syndrome (RLS) can disrupt sleep with uncomfortable sensations in the legs. While more research is needed, CBD’s muscle-relaxing properties may help ease these symptoms, making it easier to settle down and get the restful sleep you need [3].

Potential Risks of Using CBD for Sleep

While CBD is generally considered safe, there are potential risks to be aware of when using it for sleep. One common issue is drowsiness or feeling overly sedated, especially if you take too much. This can affect your ability to wake up and function normally the next day.

Additionally, CBD can have certain drug interactions, particularly with drugs that affect the liver’s ability to process substances. This interaction could potentially lead to unwanted side effects or reduce the effectiveness of your sleep medicine or other medications.

In some cases, CBD may cause mild side effects like dry mouth, dizziness, or gastrointestinal issues. While these are typically not severe, they can still be uncomfortable, especially when trying to improve your poor sleep.

Lastly, if you are pregnant, breastfeeding, or have underlying complementary and integrative health conditions, it’s important to consult with a healthcare professional before taking CBD.

Benefits of Using CBD for Sleep

There are several benefits of using cannabidiol for sleep for those who have trouble falling asleep, including:

Non-habit Forming and Safe for Regular Use

One of the standout benefits of using cannabidiol for sleep is that it’s non-habit forming, making it a safe option for regular use.

Unlike some traditional sleep aids, CBD doesn’t create dependency, allowing you to use it consistently without worrying about withdrawal or tolerance buildup.

Improved Sleep Quality and Duration

CBD has the potential to enhance both the quality and duration of your sleep. By addressing underlying issues such as pain, anxiety, or restlessness, CBD can help you fall asleep faster and enjoy a deeper, more restorative sleep throughout the night.

Natural Sleep Aid Properties of CBD

CBD offers a natural alternative to synthetic sleep aids. Its calming effect on the nervous system help promote relaxation without the grogginess often associated with over-the-counter or prescription sleep medications.

This makes it an appealing option for those looking for a more holistic approach to sleep support.

Convenient and Tasty Option for Sleep Support

CBD is available in various forms, such as gummies, tinctures, and capsules, making it a convenient and enjoyable way to support your sleep.

For example, CBD gummies provide a tasty option that can easily fit into your nightly routine, helping you wind down before bed.

Reduced Anxiety and Stress Levels

One of the primary reasons CBD is effective for sleep is its ability to reduce anxiety related disorders and stress levels.

By calming your mind and body, CBD can help you let go of the worries that keep you awake at night, allowing for a more peaceful and uninterrupted sleep experience.

>>Check the best prices for FOCL Deep Sleep Gummies

How To Find The Best CBD Sleep

To find the best cannabidiol for sleep, consider the following factors:

Assessing Flavor Options and Texture

When choosing the best cannabidiol for sleep disorder, consider the flavor options and texture. Whether you’re opting for gummies, oils, or capsules, the taste and texture can make a big difference in your overall experience.

Look for flavors that you enjoy and a texture that’s easy to incorporate into your nightly routine.

Seeking Third-Party Lab Testing and Quality Assurance

Always prioritize products that provide third-party lab testing and quality assurance. These tests confirm that the CBD is free from contaminants and that the potency matches what’s advertised.

This step ensures you’re getting a safe and effective product that delivers the expected benefits.

Considering Additional Ingredients (e.g., Melatonin)

Some CBD sleep products include additional ingredients like melatonin, chamomile, or valerian root to enhance their sleep-inducing effects.

If you’re looking for an extra boost in promoting relaxation and sleep, consider products that combine CBD with these natural sleep aids.

Checking CBD Potency and Dosage

Consider evaluating the potency and CBD dosage of the product. Depending on your sleep needs, you might require a higher or lower dose.

Start with a lower potency if you’re new to CBD, and gradually adjust until you find the dose that works best for your sleep routine.

Reading Customer Reviews and Recommendations

Customer reviews and recommendations can provide valuable insights into how well a CBD product works for sleep. Look for feedback from users with similar sleep concerns, and take note of any common experiences or issues mentioned, especially the safety and side effects.

Your Sleep Needs and Preferences

Ultimately, the best cannabidiol for sleep will align with your specific needs and preferences. Consider what’s most important to you—whether it’s flavor, ease of use, or additional sleep-promoting ingredients—and choose a product that fits seamlessly into your lifestyle for the best results.

Forms of CBD Products for Sleep

Some different forms of CBD products for sleep include:

CBD Gummies

CBD gummies are a popular and convenient option for sleep support. These tasty treats combine the benefits of CBD with enjoyable flavors and easy dosing.

Gummies are discreet and portable, making them a great choice for those who prefer a simple and delicious way to incorporate CBD into their nightly routine.

CBD Capsules

For those who prefer a no-fuss approach, CBD capsules offer a straightforward way to take cannabidiol for sleep.

Capsules provide precise dosing and are easy to swallow, making them a convenient option for consistent use. They’re also flavorless, which is ideal if you’re not a fan of the taste of other CBD products.

CBD Oils and Tinctures

CBD oils and tinctures are versatile options that allow for customizable dosing. You can take them sublingually (under the tongue) for quicker absorption or mix them into your favorite beverage.

Oils and tinctures often come in various flavors and strengths, giving you the flexibility to find the perfect balance for your sleep needs.

CBD Vape Pens

CBD vape pens provide fast-acting relief, making them a good option if you need quick results.

Vaping allows CBD to enter your bloodstream rapidly, offering relaxation almost immediately. However, if you prefer a smoke-free option, you may want to explore other forms of CBD.

CBD Topicals

While less common for sleep, CBD topicals can be helpful for those who experience discomfort or pain that keeps them awake.

Applying a CBD-infused cream or lotion to sore muscles or joints may provide localized relief, helping you relax and drift off to sleep more easily.

>>Check the best prices for FOCL Deep Sleep Gummies

FAQS

Here, we answer a few frequently asked questions about the best cannabidiol for sleep.

Is CBD Like Melatonin?

While both CBD and melatonin can aid sleep, they work differently. CBD interacts with the endocannabinoid system to promote relaxation, while melatonin is a hormone that regulates your sleep-wake cycle. Some products combine both for enhanced sleep support.

What Is the Best CBD Ratio for Sleep?

A 1:1 ratio of CBD to THC is commonly recommended for sleep, as this balance can enhance relaxation and sedation.

However, for those avoiding THC, a higher CBD ratio or pure CBD products can still offer sleep benefits. The best ratio ultimately depends on your personal tolerance and needs.

What Type of CBD is Most Effective for Sleep?

Full-spectrum CBD is most effective for sleep, especially when combined with calming cannabinoids like CBN or natural sleep aids like melatonin.

Does CBD Actually Do Anything for Sleep?

Yes, CBD can help improve sleep by reducing anxiety, easing pain, and promoting relaxation—though effects vary from person to person.

Is Just CBD Good for Sleep?

Yes, many users find Just CBD products helpful for relaxation and better sleep.

How Much CBD Does It Take to Fall Asleep?

It varies, but 25–50mg is a common starting range for sleep support.

Final Thoughts

With its wide range of therapeutic benefits, particularly its calming and relaxing properties, CBD in various forms can quickly become your go-to solution for better sleep.

When it comes to the best CBD oil for sleep, the FOCL Deep Sleep Gummies stand out, offering a potent formula with 100mg L-theanine, 25mg CBD, 15mg CBN, 2.5 mg of THC, and only 1 mg of melatonin.

The other five products we’ve highlighted also offer impressive, powerful formulations that are worth your attention. No matter which one you choose, you’re likely to find a great fit for your needs.

Remember to use CBD supplements responsibly and start with a low dose. With patience and care, you’ll soon find yourself drifting off to sleep without the need to count sheep.

References:

  1. Shannon S, Lewis N, Lee H, Hughes S. Cannabidiol in Anxiety and Sleep: A Large Case Series. Perm J. 2019;23:18-041. doi: 10.7812/TPP/18-041. PMID: 30624194; PMCID: PMC6326553.

  2. Villanueva MRB, Joshaghani N, Villa N, Badla O, Goit R, Saddik SE, Dawood SN, Rabih AM, Niaj A, Raman A, Uprety M, Calero M, Khan S. Efficacy, Safety, and Regulation of Cannabidiol on Chronic Pain: A Systematic Review. Cureus. 2022 Jul 16;14(7):e26913. doi: 10.7759/cureus.26913. PMID: 35860716; PMCID: PMC9288157.

  3. Isenmann E, Veit S, Starke L, Flenker U, Diel P. Effects of Cannabidiol Supplementation on Skeletal Muscle Regeneration after Intensive Resistance Training. Nutrients. 2021 Aug 30;13(9):3028. doi: 10.3390/nu13093028. PMID: 34578906; PMCID: PMC8469280.